Join Us
PostDoc and Students with backgrounds of Computing,Modeling and biology are welcome
Publisher:喻庆勇  Time2016-12-23 View:15

Synthetic Biology is referred to as Life Engineering since it aims at modifying cells with the insertion of DNA circuits that carry out new, specific tasks. Possible applications are diagnostic, cure of disease, biofuel production, and environmental care. Research in Synthetic Biology is both theoretical and applied. Circuits are first designed on the computer. They are associated with mathematical models such that simulations can drive their wet-lab implementation. Therefore, students with different backgrounds (e.g. computer science, physics, and biology) can do research in Synthetic Biology. In my lab, on the computational side I want to develop a stand-alone piece of software for the design of eukaryotic circuits. A user will be able to retrieve components from a database, wire them together on a Graphic User Interface or via a grammar (i.e. by specifying a list of instructions), simulate, and optimize them. Particular attention will be placed on automatic design of bio-sensing devices. These kinds of circuits will be, indeed, the main target of my wet-lab. Circuits will be assembled in yeast and will require a proper characterization of their components (promoters, mRNAs, and terminators). Yeast is the simplest eukaryotic organism and, therefore, a perfect candidate to develop models and build biosensors that might be used later into more complex hosts such as mammalian cells. Moreover, yeast is largely used in baking and brewing. Therefore, yeast cells carrying specific biosensors can be exploited to assess food quality directly. Following these lines, I have projects both for computational and experimental Synthetic Biology. Further information and a list of my publications is available at my English web page: http://210.46.81.49:8080/SLST/Pe/MarioAndreaMarchisio.html