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Chang-lin Wang
Publisher:马文君  Time2016-12-23 View:124

Chang-lin Wang

PhD,   Associate professor

E-mail:, Tel : 15104686568

Research  Area:

  • Neuropeptides Physiology & Pharmacology

  • Structure-Activity Study of Endomorphins

Resume (including education background)

  • Sc. in Biological Science, 2004, School of Life Science, Lanzhou University, China

  • D. in Biochemistry and Molecular Biology, 2009, School of Life Science, Lanzhou University, China

  • Lecturer, School of Life Science and Technology, Harbin Institute of Technology, China, 2009-2012

  • Associate Professor, Master's Supervisor, School of Life Science and Technology, Harbin Institute of Technology, China, 2012-present


  1. Wang CL, Diao YX, Xiang Q, Ren YK, Gu N. Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice E J. Pharmacol. 2014;738:1-7.

  2. Wang CL, Ren YK, Xiang Q, Wang Y, Gu N, Lu C, Wang R. Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides 2013;47:297-304.

  3. Wang CL, Zhou Y, Guo C, Zhang Y, Wang R. In vivo characterization of intestinal effects of endomorphin-1 and endomorphin-2 in type 1 diabetic mice. J. Pharmacol2013;698:499-504.

  4. Wang CL, Guo C, Wang YQ, Zhou Y, Li Q, Ni JM, Wang R. Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine. Peptides 2011;32:293-299.

  5. Wang CL, Guo C, Zhou Ying, Wang R. In vitro and in vivo characterization of opioid activities of C-terminal esterified endomorphin-2 analogs. Peptides 2009;30:1697-1704.

  6. Wang CL, Wang X, Yu Y, Cui Y, Liu HM, Lai LH, Guo C, Liu J, Wang R. Type 1 Diabetes attenuates the modulatory effects of endomorphins on mouse colonic motility. Neuropeptides 2008;42:69-77.

  7. Wang CL, Yao JL, Yu Y, Shao X, Cui Y, Liu HM, Lai LH, Wang R. Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Med. Chem. 2008;16:6415-6422.

  8. Wang CL, Yu Y, Lai LH, Cui Y, Wang X, Wang R. Cardiovascular responses to intrathecal administration of endomorphins in anesthetized rats. Peptides 2007;28:871-877.

  9. Yu Y, Wang CL, Cui Y, Fan YZ, Liu J, Shao X, Liu HM, Wang R. C-terminal amide to alcohol conversion changes the cardiovascular effects of endomorphins in anesthetized rats. Peptides 2006;27:636-643.

  10. Liu HM, Liu XF, Yao JL, Wang CL, Yu Y, Wang R. Utilization of combined chemical modifications to enhance the blood-brain barrier permeability and pharmacological activity of endomorphin-1. Pharmacol. Exp. Ther. 2006;319:308-316.

  11. Liu HM, Zhang BZ, Liu XF, Wang CL, Ni JM, Wang R. Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis and pharmacological characterization. Med. Chem. 2007;15:1694-1702.

  12. Yu Y, Cui Y, Wang X, Lai LH, Wang CL, Fan YZ, Liu J, Wang R. In vitro characterization of the effects of endomorphin 1 and 2, endogenous ligands for μ-opioid receptors, on mouse colonic motility. Pharmacol. 2007;73:1384-1393.

  13. Yu Y, Shao X, Cui Y, Liu HM, Wang CL, Fan YZ, Liu J, Dong SL, Cui YX, Wang R. Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphin 1 and 2 using an atypical constrained C terminus. ChemMedChem 2007;2:309-317.

  14. Yu Y, Shao X, Wang CL, Liu HM, Cui Y, Fan YZ, Liu J, Wang R. In vitro and in vivo characterization of opioid activities of endomorphins analogs with novel constrained C-terminus: evidence for the important role of proper spatial disposition of the third aromatic ring. Peptides 2007;28:859-870.

  15. Zhu CJ, Hu CF, Shao X, Yao JL, Wang CL, Wang R, Cui YX. Sequence and modified group analysis on C-terminal modified analogs of endomorphin-2 using electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometer. China Ser. B-Chem. 2008;51:41-45.