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Qiong Wu
Publisher:马文君  Time2016-12-23 View:237

Qiong Wu

PhD, Professor
Phone: 86-0451-86403181
Research Area: Stem Cell and Developmental Biology
Lab Home:

Professor Wu, the academic leader of developmental biology discipline, joined the School and Life Science and Technology at Harbin Institute of Technology as a professor and doctoral supervisor in 2006, right after his postdoctoral training at Niigata University. He is a graduate of Niigata University where he made parthenogenetic mice “Kaguya” and found that Igf2-H19 and Dlk1-Gtl2 are vital to the birth of mice. In addition, Dr, Wu has identified several non-coding and coding imprinted RNAs, including Meg8, AB063319 and Qpct. These non-coding RNAs were further studied to uncover their function in embryogenesis, specifically, by spatio and temporal expression by RT-PCR and ISH technology.

Dr. Wu is now a fulltime professor and an assistance dean in charge of scientific research since 2011. And he is also the secretary general of Heilongjiang province society for cell biology. His research interest is to understand the underlying mechanism how non-coding RNAs including miRNAs and lncRNAs regulate embryogenesis. To uncover the potential mechanism, Wu has focused on gene imprinting and epigenetics in mice since Ph. D. He has published over 30 SCI indexed research papers on Developmental biology and Epigenetics in Journal of Molecular Histology, Journal of Reproduction and Development, Nucleic Acids Research, Nature, Nature Biotechnology (Top journal), Scientific Reports, etc.

His lab is growing rapidly, in terms of funds, involving a total of 17 projects and 3.2 million yuan. The lab is equipped with cutting-edge instruments, supporting high-level molecular biology researches. In next years, the lab is planning to do a lot of work on interdisciplinary researches, such as non-coding RNA predictions, imprinting gene predictions and influences of environmental factors such as estrogen upon embryonic development. Given the new situation of rapid life science development, the lab has been prepared to develop into a lab with international influence.

KEY PUBLICATIONS: (* corresponding author)

  1. Liu Qi, He Hongjuan, Gu Ning, Han Zhengbin, Xing Yanjiang, Zeng Tiebo, Huang Zhijun, Wu Qiong*. miR-370 isstage-specifically expressed during mouse embryonic development and regulates Dnmt3a. FEBS Letters. 2013, 587(6):775-81

  2. Jie Lv, Hongbo Liu, Zhijun Huang, Jianzhong Su, Hongjuan He, Youcheng Xiu, Yan Zhang, Qiong Wu*. Long non-coding RNA identification over mouse brain development by integrative modeling of chromatin and genomic features. Nucleic Acids Research. 2013, 10.1093/nar/gkt818

  3. Hongbo Liu, Yanjun Chen, Jie Lv, Hui Liu, Rangfei Zhu, Jianzhong Su, Xiaojuan Liu, Yan Zhang and Qiong Wu*. Quantitative epigenetic co-variation i n CpG islands and co-regulation of developmental genes. Scientific Reports. 2013, 3, 2576.

  4. Jie Lv, Wei Cui, Hongbo Liu, Hongjuan He, Youcheng Xiu, Jing Guo, Hui Liu, Qi Liu, Tiebo Zeng, Yan Chen, Yan Zhang, Qiong Wu*. Identification and Characterization of Long Non-Coding RNAs Related to Mouse Embryonic Brain Development from Available Transcriptomic Data. PLoS ONE. 2013, 8(8):e71152

  5. Tiebo Zeng, Hongjuan He, Fengwei Zhang, Zhengbin Han, Zhijun Huang, Qi Liu, Qiong Wu*. Expression analysis of AK003491, an imprinted noncoding RNA, during mouse development. Genes & genetic systems. 2013, 88(2):127-33

  6. Zhijun Huang, Qiong Wu*. Spatiotemporal expression of retrogene-host pair Mcts2/H13 i n mouse embryo, and Mcts2 has no influence on H13 transcription patterns. Acta Histochemica. 2013, In press.

  7. Zhengbin Han, Qi Liu, Zhijun Huang, Wei Cui, Yijun Tian, Weili Yan, Qiong Wu*. Expression and imprinting analysis of AK044800, a transcript from the Dlk1-Dio3 imprinted gene cluster during mouse embryogenesis. Molecules & Cells. 2013, 35(4):285-90

  8. Xue Xiao, Zhe Li, Hongbo Liu, Jianzhong Su, Fang Wang, Xueting Wu, Hui Liu, Qiong Wu, Yan Zhang*. Genome-wide identification of Polycomb target genes i n human embryonic stem cells. Gene. 2013, 18(2):425-30

  9. Tiantian Gu, Hongjuan He, Yan Zhang, Zhengbin Han, Zhijun Huang, Tiebo Zeng,Qi Liu, and Qiong Wu*. Trmt112 Gene Expression i n Mouse Embryonic Development. Genes to Cells. 2012, 45(2): 113–119

  10. Lin Yang, Jia-Hou Chen, Jie Lv, Qiong Wu, Tong Xu, Hua Zhang, Qiao-Hong Liu and Hong-Kun Yang. Rice protein improves adiposity, body weight and reduces lipids level i n rats through modification of triglyceride metabolism. Lipids i n Health and Disease. 2012, 11:24

  11. Zhengbin Han, Hongjuan He, Fengwei Zhang, Zhijun Huang, Ziguang Liu, Huijie Jiang, Qiong Wu*. Spatiotemporal expression pattern of Mirg, an imprinted non-coding gene, during mouse embryogenesis. Journal of Molecular Histology. 2012, 43(1):1-8

  12. QianQian Xu, FengWei Zhang, HongJuan He, ShengQiang Xu, Kai Li,ShanShan Liu, Yu Li and Qiong Wu*. Expression profile of mouse Mterfd2, a novel componentof the mitochondrial transcription terminationfactor (MTERF) family. Genes & Genetic Systems. 2011, 86(4):269-75

  13. Gu Tiantian, He Hongjuan, Han Zhengbin, Zeng Tiebo, Huang Zhijun, Liu Qi, Gu Ning, Chen Yan, Sugimoto Kenkichi, Jiang Huijie, Wu Qiong*. Expression of macro non-coding RNAs Meg8 and Irm i n mouse embryonic development. Acta Histochemica. 2012,114(4):392-9.

  14. Xing Yanjiang, He Hongjuan, Gu Tiantian, Zhang Yan, Huang Zhijun, Wu Qiong*. Expression Patterns of Ubiquitin Conjugating Enzyme UbcM2 During Mouse Embryonic Development. Gene Expression. 2012,15(4):163-70.

  15. Tiantian Gu, Hongjuan He, Yanjiang Xing, Qi Liu, Ning Gu, Sugimoto kenkichi, Huijie Jiang and Qiong Wu*. Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. Journal of Molecular Histology. 2011, 42(2):105-12

  16. Zeng F, Tian Y, Shi S, Wu Q, Liu S, Zheng H, Yue L, Li Y. Identification of mouse MARVELD1 as a microtubule associated protein that inhibits cell cycle progression and migration. Molecules & Cells. 2011, 31(3):267-74.

  17. Chen Yan, He hongjuan, Hou Jing, Zhang fengwei, Han zhengbin and Wu Qiong*. Expression patterns of imprinted gene Inpp5f-v3 during mouse brain development. Journal of Molecular Histology. 2011, 42(2):167-73

  18. Zhong, Xiuying; Yoshioka Asami; Mashio Yuka; Ikeda Toru; Jiang Huijie; Tohma Maki; Wu Qiong*; Wang Changliu; Sugimoto Kenkichi. Effect of vegf gene knock down on growth of murine sarcoma cell line MS-K. Genes to Cells. 2011, 16(6):625-38

  19. Jianzhong Su,Haidan Yan, Yanjun Wei, Hongbo Liu, Hui Liu, Fang Wang, Jie Lv, Qiong Wu, Yan Zhang. CpG_MPs: identification of CpG methylation patterns of genomic regions from high-throughput bisulfite sequencing data. Nucleic Acids Research. 2013, 41(1):e4.

  20. Jie Lv, Hongbo Liu, Jianzhong Su, Xueting Wu, Hui Liu, Boyan Li, Xue Xiao, Fang Wang, Wu Qiong*,Yan Zhang*. DiseaseMeth: a human disease methylation database. Nucleic Acids Research. 2012 40(Database issue):D1030-5.

  21. Jianzhong Su*, Xiujuan Shao, Hongbo Liu, Shengqiang Liu, Qiong Wu, Yan Zhang*. Genome-wide dynamic changes of DNA methylation of repetitive elements i n human embryonic stem cells and fetal fibroblasts. Genomics. 2012, Jan;99(1):10-7.

  22. Feng Wei Zhang,Zheng Bin Han,Chang Yan Deng,Hong Juan He,Yan Chen,Ning, Gu,Qiong Wu*. Conservation of genomic imprinting at the NDN, MAGEL2 and MEST loci i n the pigs. Genes & Genetic Systems. 2012, 87(1):53-8.

  23. Feng Wei Zhang, Dong Wan Zhao, Tie Bo Zheng, Meng Ya Gao, Zheng Bin Han, Hong Juan He, Yan Chen, Ning Gu,Qiong Wu*. Imprinting and expression analysis of a non-coding RNA gene i n the mouse Dlk1-Dio3 domain. Journal of Molecular Histology. 2011, 42(4):333-9

  24. Yan Zhang*, Hongbo Liu, Jie Lv, Xue Xiao, Jiang Zhu, Xiaojuan Liu, Jianzhong Su, Xia Li, Qiong Wu, Fang Wang, Ying Cui. QDMR: A quantitative method for identification of differentially methylated regions (DMRs) by entropy. Nucleic Acids Research. 2011, 39(9):e5826 Yan Zhang*, Jie Lv, Hongbo Liu, Jiang

  25. Zhu, Jianzhong Su, Qiong Wu, Yunfeng Qi, Fang Wang, Xia Li*. HHMD: the human histone modification database. Nucleic Acids Research. 2010, 38(Database issue):D149-D154

  26. Kawahara M, Wu Q, Kono T. Involvement of Insulin-like Growth Factor 2 i n Angiogenic Factor Transcription i n Bi-maternal Mouse Conceptuses. Journal of Reproduction and Development. 2010, 56(1):79-85

  27. Jie Lv, Hongbo Liu, Qiong Wu*, Yan Zhang*. High-Throughput Computational Approaches to Analyzing Histone Modification Next-Generation Sequencing Data. Computational Molecular Biology. 2012, Vol. 2, No. 1

  28. Mengya Gao, Qi Liu, Fengwei Zhang,Zhengbin Han, Tiantian Gu, Weiming Tain, Yan Chen and Qiong Wu*. Expression of PRELI Domain Containing 2 Gene (PRELID2) During Mouse Embryonic Development. Journal of Molecular Histology. 2009, 40(3):227-233

  29. Liu Qi,Wang Yan, Chen Yan, Zhang Fengwei, GU Tiantian,Qu Youpeng, Yu Lei and Qiong Wu*. The expression analysis of Grb10 during mouse embryonic development. Hereditas. 2009, 31(7):732-740

  30. Gu Tian-tian, Zeng Tie-bo, Xu Shengqiang, Chen yan, Zhang Fengwei, Wu Qiong*. Study on a Novel Gene Involved i n Mouse Embryonic Development. Progress i n modern biomedicine. 2009, 9(2):212-215

  31. Qiong Wu*, Manabu Kawahara, Nozomi Takahashi and Tomohiro Kono. Synergistic role of Igf2 and Dlk1 i n foetal liver and hematopoiesis i n bi-maternal mice. Journal of Reproduction and Development. 2008, 54(3):177-182

  32. Kawahara M, Qiong Wu*, Ferguson-Smith AC, Kono T. Appropritate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term. FEBS Letters. 2007, 581(27):5178-84

  33. Kawahara M, Qiong Wu*, Takahashi N, Morita S, Yamada K, Ito M, Ferguson-Smith AC, Kono T. High-frequency generation of viable mice from engineered bi-maternal embryos. Nature Biotechnology. 2007, 25(9):1045-1050

  34. Ogawa H, Qiong Wu*, Komiyama J, Obata Y, Kono T. Disruption of parental- specific expression of imprinted genes i n uniparental fetuses. FEBS Lett. 2006, 580(22):5377-5384

  35. Manabu Kawahara, Qiong Wu*, Yukio Yaguchi, Anne C. Ferguson-Smith, Tomohiro Kono. Complementary roles of genes regulated by two paternally imprinted regions on chromosomes 7 and 12 i n placentation of mouse parthenotes. Human Molecular Genetics. 2006, 15(19):2869-2879

  36. Kono T, Kawahara M, Qiong Wu*, Hiura H, Obata Y. Paternal dual barrier by Ifg2-H19 and Dlk1-Gtl2 to parthenogenesis i n mice. Ernst Schering Res Found Workshop. 2006, (60):23-33

  37. Qiong Wu, Takuya Kumagai, Manabu Kawahara, Hidehiko Ogawa, Hitoshi Hiura,Yayoi Obata, Riya Takano and Tomohiro Kono. Regulated expression of two sets of paternally imprinted genes is necessary for mouse parthenogenetic development to term. Reproduction. 2006, 131(3):481-488

  38. Kono T, Obata Y, Qiong Wu, Niwa K, Ono Y, Yamamoto Y, Park ES, Seo JS, Ogawa H. Birth of parthenogenetic mice that can develop to adulthood. Nature. 2004, 428(6985):860-864 (This paper has been cited by 268 times)