Guangli Cao

PhD, Associate Professor

Phone:86-0451-86402652

Email: caogl@hit.edu.cn

Area of interest:  Biological Engineering and Bioenergy

Dr. Guangli Cao is an associate professor of School of Life Science and Technology, Harbin Institute of Technology. She earned her PhD degree from Harbin Institute of Technology in Environmental Sciences in 2010. She has a broad background in bioscience and bioengineering, and has authored numerous journal papers. Her research addresses fundamental topics in biological engineering as it applies to bioproducts and bioconversion.

Research Description

We use multi-disciplinary approaches including biochemistry, molecular biology, transgenetic and ecological technology. Our research interests mainly focus on:

1. Exploitation of microorganisms for the production of microbial enzymes (Submerged and Solid State Fermentation)and bioenergy from lignocellulosic feedstock.

2. Designing of bioreactors based on their applications – Fed-batch operations, Continuous fermentations(Developmentof bioreactors for immobilization of whole cells or cell free extracts).

3. Downstream recovery of microbial derived products-extra cellular and intracellular enzymes, solvents and single cellprotein etc.

4. Strain improvement by conventional methods-Mutagenesis, protoplast fusion, and recombinant DNA technology.

Integration and optimization of biorefinery system.

publications

2016

1. ChengJiang,Guangli Cao, Zhehyu Wang, Qian Yang*. Enhanced Butanol Production Through Adding Organic Acids and Neutral Red by Newly Isolated Butanol-Tolerant Bacteria.Appl Biochem Biotechnol. 2016,180(7) : 1416-1427

2015

1. Zhen-Yu Wang^#,Guang-Li Cao^#, Ju Zheng, De-Feng Fu, Jin-Zhu Song, Jun-Zheng Zhang, Lei Zhao, Qian Yang*. Developing a mesophilic co-culture for direct conversion of cellulose to butanol in consolidated bioprocess. Biotechnology for Biofuels 2015, 8:84.

2. Guang-Li Cao, Eduardo Ximenes, Nancy N. Nichols, Sarah E. Frazer, Daehwan Kim, Michael A. Cotta, Michael Ladisch*. Bioabatement with hemicellulase supplementation to reduce enzymatic hydrolysis inhibitors. Bioresource Technology. 2015, 190: 412-415.

 2014

1. Guang-Li Cao, Lei Zhao, Ai-Jie Wang, Zhen-Yu Wang and Nan-Qi Ren*. Single-step bioconversion of lignocelluloseto hydrogen using novel moderately thermophilic bacteria. Biotechnology for Biofuels 2014, 7:82.

2. Lei Zhao, Guang-Li Cao*, Ai-Jie Wang, Hong-Yu Ren, Kun Zhang and Nan-Qi Ren. Consolidated bioprocessing performance of Thermoanaerobacterium thermosaccharolyticum M18 on fungal pretreated cornstalk for enhanced hydrogen production. Biotechnology for Biofuels 2014, 7:178.

3. Cheng-Jiao Xu,Guang-Li Cao*, Lei Zhao, Ai-Jie Wang, Lin-Na Chen, Nan-Qi Ren. A dual-chamber reactor to assess the saccharification capability of the cellulytic microflora from straw waste. RSC Advances. 4: 9617-9621, 2014.

4. Lei Zhao,Guang-Li Cao*, Ai-Jie Wang, Hong-Yu Ren, Nan-Qi Ren. An anaerobic sequential batch reactor for enhanced continuous hydrogen production from fungal pretreated cornstalk hydrolysate. International Journal of Hydrogen Energy. 2014,39.

2013

1. Guang-Li Cao, Xun-Feng Xia*, Zhao L, Zhen-Yu Wang, Xuan Li, Qian Yang. Development of AFEX-based

   consolidated bioprocessing on wheat straw for biohydrogen production using anaerobic microflora. International

   Journal of Hydrogen Engergy. 38: 15653-15659, 2013.

2. Guang-Li Cao, Eduardo Ximenes, Nancy Nichols, Le-Yu Zhang, Michael Ladisch*. Biological abatement of

   cellulase inhibitors. Bioresource Technology. 146:604–610, 2013.

3. Lei Zhao,Guang-Li Cao*, Jing Yao, Hong-Yu Ren, Cheng-Jiao Xu, Nan-Qi Ren. Enzymatic Saccharification of

   Cornstalk by Onsite Cellulases Produced by Trichoderma viride for Enhanced Biohydrogen Production. GCB

   Bioenergy. 5(5): 591-598, 2013.

4. Lei Zhao,Guang-Li Cao*, Ai-Jie Wang, Hong-Yu Ren, Nan-Qi Ren. Evaluation of continuous biohydrogen

   production from enzymatically treated cornstalk hydrolysate. International Journal of Hydrogen Engergy. 38:

   15100-15104, 2013.

5. Zheng-Yu Wang,Guang-Li Cao, Cheng Jiang, Jin-Zhu Song, Ju Zheng, Qian Yang*. Butanol Production from

   Wheat Straw byCombining Crude Enzymatic Hydrolysis and Anaerobic Fermentation Using Clostridium

   acetobutylicum ATCC824. Energy &Fuels, 27(10): 5900-5906, 2013.

6. Lei Zhao,Guang-Li Cao,Ai-Jie Wang, Hong-Yu Ren, Nan-Qi Ren*. Simultaneous saccharification and

   fermentation of fungalpretreated cornstalk for hydrogen production using Thermoanaerobacterium

   thermosaccharolyticum W16. Bioresource Technology.145:103-107, 2013.

2012

1. Guang-Li Cao,Wan-Qian Guo,Ai-Jie Wang,Lei Zhao,Cheng-Jiao Xu,Nan-Qi Ren*. Enhanced cellulosic hydrogen

   production from lime-treated cornstalk wastes using thermophilic anaerobic microflora.International Journal of

   Hydrogen Energy. 2012, 37(17):13161–13166.

2. Lei Zhao,Guang-Li Cao, Ai-Jie Wang, Wan-Qian Guo, Bing-Feng Liu, Hong-Yu Ren, Nan-Qi Ren*, Fang Ma.

   Enhanced bio-hydrogen production by immobilized Clostridium sp. T2 on a new biological carrier. International

   Journal of Hydrogen Energy. 2012, 37, 162–166.

3. Lei Zhao,Guang-Li Cao, Jing Yao, Hong-Yu Ren, Fang Ma, Nan-Qi Ren, Ai-Jie Wang*. Optimization of

   immobilization parameters of Thermoanaerobacterium thermosaccharolyticum W16 on a new carrier for enhanced

   hydrogen production. RSC Advances. 2012, 2, 7391-7395.

4. Lei Zhao,Guang-Li Cao, Jing Yao, Hong-Yu Ren, Cheng-Jiao Xu, Nan-Qi Ren, Ai-Jie Wang*. Fungal

   pretreatment of cornstalk with Phanerochaete chrysosporium for enhancing enzymatic saccharification and

   hydrogen production. Bioresource Technology. 2012, 114:365–369.

5. Shan-Shan Yang, Wan-Qian Guo,Guang-Li Cao, Nan-Qi Ren*. Simultaneous waste activated sludge

   disintegration and biologicalhydrogen production using an ozone/ultrasound pretreatment Bioresource Technology.

   2012,124: 347–354.

2011

1. Kun Zhang, Nan-Qi Ren*,Guang-Li Cao, Ai-Jie Wang. Biohydrogen production behavior of moderately

   thermophile Thermoanaerobacterium thermosaccharolyticum W16 under different gas-phase conditions.

   International Journal of Hydrogen Energy. 2011, 36: 14041~14048.

2. Ai-Jie Wang, Dan Sun,Guang-Li Cao, Ha-Yu Wang, Nan-Qi Ren, Wei-Min Wu, Bruce E Logan*. Integrated

   hydrogen production process from cellulose by combining dark fermentation, microbial fuel cells, and a microbial

   electrolysis cell. Bioresource Technology. 2011, 102: 4137–4143.

3. N.Q. Ren*, W.Q. Guo, B.F. Liu, G.L. Cao, J. Ding. Biological hydrogen production by dark fermentation:

   challenges and prospects towards scaled-up production. Current Opinion in Biotechnology.

4. Guo WQ,  DingJ,Cao GL, Ren NQ, Cui FY. Treatability study of using low frequency ultrasonic pretreatment to

   augment continuous biohydrogen production. Int J Hydrogen Energy. 2011 , 36 (21) :14180-14185

2010

1. Guang-Li Cao, Nan-Qi Ren*, Ai-Jie Wang. Effect of lignocellulose-derived inhibitors on growth and  hydrogen

   production by Thermoanaerobacterium thermosaccharolyticum W16. International Journal of Hydrogen Energy.

   2010, 35: 13475-13480.

2. Guang-Li Cao, Nan-Qi Ren*, Ai-Jie Wang, Wan-Qian Guo, Jing Yao, Yu-Jie Feng, Qing-Liang Zhao. Statistical

   optimization of culture condition for enhanced hydrogen production by Thermoanaerobacterium

   thermosaccharolyticum W16. Bioresource Technology. 2010, 101(6): 2053-2058.

3. Guang-Li Cao, Nan-Qi Ren*, Ai-Jie Wang, Jing Yao, Kun Zhang, Cheng-Jiao Xu. Combination of mild chemical

   pretreatment with biological conversion for enhanced hydrogen production from cornstalk wastes. Journal of

   Biotechnology. 2010, 150S: S9.

4. Guang-Li Cao, Nan-Qi Ren*, Ai-Jie Wang, Jing Yao, Kun Zhang. Direct convertion of cellulosic substrate to

   hydrogen production by Clostridium cellulosi D3. Journal of Biotechnology. 2010, 150S: S563.

5. Nan-Qi Ren*,Guang-Li Cao, Wan-Qian Guo, Ai-Jie Wang. Biological hydrogen production from corn stover by

   moderately thermophile Thermoanaerobacterium thermosaccharolyticum W16. International Journal of Hydrogen

   Energy. 2010, 35: 2708-2712.

2009

1. Cao GL, Ren NQ, Wang AJ, Guo WQ. Acid hydrolysis of corn stover for biohydrogen production using

   Thermoanaerobacterium thermosaccharolyticum W16. International Journal of Hydrogen Energy. 2009, 34(17):

   7182-7188.

2. Ren NQ, Wang AJ,Cao GL, Xu JF, Gao LF. Bioconversion of Lignocellulosic Biomass to Hydrogen: Potential

   and Challenges. Biotechnology Advances. 2009, 27(6): 1051-1060.