Work Experience

2015 – present     Professor. Northeast Normal University, Changchun

2009 – 2015        Postdoctoral training. Medical School University of Michigan.

Education

2004 – 2009Ph.D. in Cell biology

Institute of Biophysics, Chinese Academy of Sciences, Beijing.

2000 – 2004B.S. in Biotechnology

Shandong Normal University, Jinan.

Honors and Awards

Shandong Normal University scholarship, 2001-2004

Chinese Academy of Sciences scholarship, 2006-2009

Best poster, 3rd University of Michigan-Wayne State University Symposium 2012

Travel Award, Endocrine Society 2014

Selected Publications

1. Ren X, Li X, Jia L, Chen D, Hou H, Rui L, Zhao Y,Chen Z*. A small-molecular inhibitor of NF-kB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury.FASEB Journal.2017 31(2):711-718

2. Tao L, Jia L, Li Y, Song C,Chen Z*.Recent advances of adapter proteins in the regulation of heart diseases.Heart Fail Rev.2017 22(1):99-107

3. Chen Z*. Adapter proteins regulate insulin  resistance and lipid metabolism in obesity.Science Bulletin. 2016 61:1489-1497 

4. Qin W, Li X, Xie L, Li S, Liu J, Jia L, Dong X, Ren X, Xiao J, Yang C, Zhou Y, andChen Z*.  A long non-coding RNA, APOA4-AS, regulates APOA4 expression depending on HuR in mice.Nucleic Acids Research.2016 44(13):6423-33. 

5. Chen Z*.  Progress and prospects of long noncoding RNAs in lipid homeostasis.Molecular Metabolism20165(3), 164-170

6. Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K,Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM.HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.Cell Metab. 2016 Mar 8;23(3):505-16.

7. Chen Z., Canet, M. J., Sheng, L., Jiang, L., Xiong, Y., Yin, L., and Rui, L. Hepatocyte TRAF3 promotes insulin resistance and type 2 diabetes in mice with obesity.Molecular Metabolism2015 4, 951-960 

8. Jiang B, Shen H,Chen Z, Yin L, Zan L, Rui L.Carboxyl terminus of HSC70-interacting protein (CHIP) downregulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury.J Biol Chem.2015 May 1;290(18):11704-14.

9. Chen Z, Shen H, Sun C, Yin L, Tang F, Zheng P, Liu Y, Brink R, Rui L.Myeloid Cell TRAF3 Promotes Metabolic Inflammation, Insulin Resistance, and Hepatic Steatosis in Obesity.Am J Physiol Endocrinol Metab.2015 Mar 15;308(6):E460-9.

10. Sun J, Cui J, He Q,Chen Z, Arvan P, Liu M.Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Mol Aspects Med. 2015 Jan 8. pii: S0098-2997(15)00002-3.

11. Shen H, Sheng L,Chen Z, Jiang L, Su H, Yin L, Omary MB, Rui L.Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis.Hepatology. 2014 Dec;60 (6):2065-76. 

12. Yuan Q*,Chen Z* (co-first author), Santulli G, Gu L, Yang ZG, Yuan ZQ, Zhao YT, Xin HB, Deng KY, Wang SQ, Ji G. Functional role of calstabin 2 in age-related cardiac alterations.Sci Rep.2014 Dec 11;4:7425. 

13. Chen Z, Morris DL, Lin J, Liu Y, Rui L. SH2B1 in β cells regulates glucosemetabolism by promoting β cell survival and islet expansion.Diabetes.2014, 63 (2), 585-595PMID: 24150605. 

14. Chen Z, Morris DL, Lin J, Liu Y, Rui L. SH2B1 in β cells promotes insulin expression and glucose metabolism in mice.Molecular Endocrinology.2014, 28 (5), 696-705 PMID: 24645678. 

15. Sheng L, Liu Y, Jiang L,Chen Z, Zhou Y, Cho KW, Rui L. Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice.PloS One. 2013, 8(12):e83269. 

16. Chen Zheng.Nuclear Medicine Contributes to the Identification of Brown Adipose Tissue in Adult Human.J NuclMed Radiat Ther2012, 3:5 (Editorial Article)

17. Sheng L, Zhou Y,Chen Z, Ren D, Cho KW, Jiang L, Shen H, Sasaki Y, Rui L.,NF-kB-inducing Kinase (NIK) Promotes Hyperglycemia and Glucose Intolerance in Obesity by Augmenting Glucagon Action.Nature medicine.2012, 18: 943-949PMID: 22581287.

18. Shen H, Shao M, Cho KW, Wang S,Chen Z, Sheng L, Wang T, Liu Y, Rui L. Herbal Constituent Sequoyitol Improves Hyperglycemia and Glucose Intolerance by Targeting Hepatocytes, Adipocytes, and β cells.Am J Physiol Endocrinol Metab.2012, 302 (8): E932-40. PMCID: PMC3330724. 

19. Chen Z, Sheng L, Shen H, Zhao Y, Wang S, Brink R, Rui L. Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.Diabetes2012, 61:566-573. PMCID: PMC3282816. 

20. Pan C, Zhou R,Chen Z, Chen Y, Wu Y, Miao L, Yin W, Ji G. ERp44 Mediates Gene Transcription via Inositol 1, 4, 5-trisphosphate Receptors in Hela Cells. Progress in Biochemistry and Biophysics2011, 38(8): 706~712. 

21. Tong X,Muchnik M,Chen Z,Patel M,Wu N,Joshi S,Rui L,Lazar MA,Yin L. Transcriptional Repressor E4 Binding Protein 4 (E4BP4) Regulates Metabolic Hormone Fibroblast Growth Factor 21 (FGF21) during Circadian Cycles and Feeding. J Biol Chem.2010 285(47):36401-9. PMID:20851878.

22. Wang X,Xie W,Zhang Y,Lin P,Han L,Han P,Wang Y,Chen Z,Ji G,Zheng M,Weisleder N,Xiao RP,Takeshima H,Ma J,Cheng H. Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair.Circ Res. 2010 107(1):76-83. PMID: 20466981.

23. Chen Z, Li Z, Wei B, Yin W, Xu T, Kotlikoff MI, Ji G.FKBP12.6-knockout mice display hyperinsulinemia and resistance to high-fat diet-induced hyperglycemia.FASEB J. 2010 24: 357-363. PMCID: PMC2812035. 

24. Zhang X*, Tallini YN*,Chen Z*(co-first author), Gan L, Wei B, Doran R, Miao L, Xin HB, Kotlikoff MI, Ji G.Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes.Cardiovasc Res. 2009 Nov 1;84(2):253-62. PMCID: PMC2761199. 

25. Chen Z, Li Z, Peng G, Chen X, Yin W, Kotlikoff MI, Yuan ZQ, Ji G.Extracellular ATP-induced nuclear Ca2+ transient is mediated by inositol 1,4,5-trisphosphate receptors in mouse pancreatic beta-cells.BiochemBiophys Res Commun. 2009 May 1;382(2):381-4. PMID: 19285037. 

26. Wei B*,Chen Z*(co-first author), Zhang X, Feldman M, Dong XZ, Doran R, Zhao BL, Yin WX, Kotlikoff MI, Ji G.Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.PLoS One.2008 Jun 25;3(6):e2526. PMCID: PMC2424173. 

27. Zhang LQ*, Zhang HJ*, Guo P, Xue P, Xie ZS,Chen Z, Jing GZ.C-terminal effect of Thermoanaerobacter tengcongensis ribosome recycling factor on its activity and conformation changes.Arch Biochem Biophys. 2007 Oct 15;466(2):211-20. PMID: 17697668. 

28. Wang M,Chen Z, Xing Y, Zhang X, Dong XZ, Ji GJ.Localized Ca2+ uncaging induces Ca2+ release through IP3R in smooth muscle.Acta Pharmacol Sin. 2006 Jul;27(7):939-44. PMID: 16787580.