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Ning Gu
Publisher:马文君  Time2016-12-23 View:20

Ning Gu

PhD, Professor, Doctoral supervisor

Phone: 86-0451-86403181

Email: guning@hit.edu.cn

Research Area: Pharmacology and endocrine diseases

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Ning Gu, professor and doctoral supervisor of pharmacology and endocrine diseases discipline. He graduated with his bachelor’s degree from Kyoto University of Education (1998.42002.3), later got his master’s degree from Kyoto University (2002.42004.3), and then got his doctor’s degree from Kyoto University (2004.42007.3). After the graduated he joined Japan Society for the Promotion of Science (JSPS) of Kyoto University as a researcher. Then he joined Advanced Industrial Science and Technology (AIST) as a researcher in 2009. He returned to China and joined the School and Life Science and Technology at Harbin Institute of Technology in 2010.


Research Description

Dr. Gu is now a fulltime professor and doctoral supervisor in charge of scientific research. His main research interests are in four research areas:

1). The studying on the pathogenesis and therapeutic method of diabetes, obesity and other endocrine diseases.

Diabetes is an endocrine system disease characterized by elevated plasma glucose levels resulting from either a lack of insulin production or resistance to insulin. According to statistics, a relatively small proportion (10%) of patients suffering from diabetes mellitus has type I or insulin dependent diabetes. The majority of diabetes patients are type II diabetes whose main mechanism is insulin resistance. Obesity is a major public health concern worldwide that can increase the risk of type II diabetes. Our studies aim to intensive research type II diabetes from several pathways, such as endoplasmic reticulum stress, oxidative stress and so on, clearing the pathogenesis of diabetes, obesity and other endocrine diseases, and find therapeutic method of these diseases.

2). The studying on the pharmacological and toxicological of nanoparticles and micromolecular compounds.

Nanotechnology and micromolecular compounds have become widely utilized in many fields. To fully exploit their potential application value and potential harm, we devoted to pharmacological and toxicological researches of nanoparticles and micromolecular compounds. We have developed a complete evaluation system of pharmacological and toxicological of nanoparticles and micromolecular compounds, and has effectively applied it to some in vivo and in vitro toxicological researches of some nanoparticles and micromolecular compounds.

3). The studying on the mechanism of proliferation and differentiation of stem cell, and reprogramming of somatic cells.

Somatic cells can be reprogrammed into Induced Pluripotent Stem Cells (iPSCs) by the enforced expression of defined transcription factor combinations. However, there are still many knowledge gaps hamper the development and utilization of iPSCs and its technology. To harness the full potential of iPSC technology, we are studying on mechanism of proliferation and differentiation of stem cell, and reprogramming of somatic cells, and in search for the safety and high efficiency utilization method.

In recent years, his projects include The Studying on the Effects and Mechanisms of Nanoparticles to Plasma Glucose Metabolism of Mice During Different Development Period (the National Natural Science Foundation of China), and The Studying on the Mechanism of TiO2 Nanoparticles on Plasma Glucose Metabolism in the Water Environment (the State Key Laboratory Project of City Water Resources and Water Environment), The Studying on Inducing Fibroblast Direct Reprogramming to Cartilage Cell by Recombinant Protein Specific Transcription Factor and Its Security (the National Natural Science Foundation of China), and The Studying on Improving the Proliferation Ability of Mesenchymal Stem Cell by Transcription Factor Recombinant Protein (the Overseas Foundation of Heilongjiang Province), and The Studying on Toxicological Effects of the Nanoparticles on the Endocrine System and the Mechanism in the Water Environment (the State Key Laboratory Project of City Water Resources and Water Environment), and The Studying on Improving the Efficitency of iPS cells Inducing by Recombinant Protein (the National Natural Science Foundation of China).


Publications

His studies are published in the Diabetes Technology & Therapeutics, Clinical and Experimental Pharmacology and Physiology, Biochemical and Biophysical Research Communications, Journal of Nutritional Science and Vitaminology, etc. The total number is over 20 papers:

1) Guo Qian, Jin Sanli, Hu Hailong, Zhou Ying, Yan Yuheng, Zong He, Wang Yu, He Hongjuan, Oh Yuri, Liu Chuanpeng, Gu Ning. Hypoxia in 3T3-L1 adipocytes suppresses adiponectin expression via the PERK and IRE1 unfolded protein response. Biochem Biophys Res Commun 2017 Sep;.

2) Hu Hailong, Li Li, Guo Qian, Jin Sanli, Zhou Ying, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning, A mechanistic study to increase understanding of titanium dioxide nanoparticles-increased plasma glucose in mice.Food Chem Toxicol. 2016 Sep;95:175-81.

3) Gu Ning, Hu Hailong, Guo Qian, Jin Sanli, Wang Changlin, Oh Yuri, Feng Yujie, Wu Qiong, Effects of oral administration of titanium dioxide fine-sized particles on plasma glucose in mice. Food Chem Toxicol, 2015, 86:124-131.

4) Gu Ning, Guo Qian, Mao Ke, Hu Hailong, Jin Sanlin, Zhou Ying, He Hongjuan, Oh Yuri, Liu Chuanpeng, Wu Qiong, Plasmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes. Biochem Biophys Res Commun, 2015, 467: 521-526.

5) Hu Hailong, Guo Qian, Wang Changlin, Ma Xiao, He Hongjuan, Oh Yuri, Feng Yujie, Wu Qiong, Gu Ning, Titanium dioxide nanoparticles increase plasma glucose via reactive oxygen species-induced insulin resistance in mice. J. App. Toxicol. 2015.

6) Hu Hailong, Li Li, Wang Changlin, He Hongjuan, Mao Ke, Ma Xiao, Shi Ruoyu, Oh Yuri, Zhang Fengwei, Lu Ying, Wu Qiong, Gu Ning, 4-Phenylbutyric acid increases GLUT4 gene expression through suppression of HDAC5 but not endoplasmic reticulum stress. Cell Physiol Biochem. 2014;33(6):1899-910.

7) Wang CL, Diao YX, Xiang Q, Ren YK, Gu Ning, Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice. Eur J Pharmacol. 2014 Sep 5;738:1-7.

8) Wang CL, Xiang Q, Diao YX, Ren YK, Gu Ning, Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice. Eur J Pain. 2014 Sep;18(8):1157-64.

9) Wang CL, Ren YK, Xiang Q, Wang Y, Gu Ning, Lu C, Wang R, Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides. 2013 Oct;47(5):297-304.

10) Gu Tiantian, He Hongjuan, Xing Yanjiang, Liu Qi, Gu Ning, Sugimoto Kenkichi, Jiang Huijie and Wu Qiong. Expression of non-coding RNA AB063319 derived from Rian gene during mouse development. J Mol Histol. 2011 Feb 9  [Epub ahead of print]

11) Ikegami Dasuke, Iwai T, Ryo Senyi, Gu Ning, Sugiyama Tasuke, Oh Isamu, Yoshikawa Hiroyuki, Tsumaki Nobuyuki. Identification of small molecular compounds and fabrication of its aqueous solution by laser-ablation, expanding primordial cartilage. Osteoarthritis Cartilage. 19(2), 233-41 2011.

12) Gu Ning, Nagatomo Fumiko, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Effects of hyperbaric oxygenation on oxidative capacity in the soleus and plantaris muscles of type 2 diabetic rats. Diabetes Technol. Ther. 12(2):125-133, Feb, 2010.

13) Gu Ning, Tsuda Mariko, Matsunaga Tetsuro, Adachi Tetsuya, Yasuda Koichiro, Ishihara Akihiko, Tsuda Kinsuke. Glucose regulation of DPP-IV gene expression is mediated by HNF-1alpha in epithelial intestinal cells. Clin Exp Pharm Phys. 35(12), 1433-1439, May, 2008.

14) Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. HNF-1alpha participates in glucose regulation of sucrase-isomaltase (SI) gene expressions in small intestinal epithelial cells. Biochem Biophys Res Commun. 353(3), 617-622, Feb, 2007.

15) Gu Ning, Adachi Tetsuya, Matsunaga Tetsuro, Takeda Jun, Tsujimoto Gozoh, Ishihara Akihiko, Yasuda Koichiro, Tsuda Kinsuke. Mutant HNF-1alpha and mutant HNF-1beta identified in MODY3 and MODY5 downregulate DPP-IV gene expression in Caco-2 cells. Biochem Biophys Res Commun. 346(3), 1016-1023, Aug, 2006.

16) Gu Ning, Adachi Tetsuya, Takeda Jun, Aoki Norihiko, Tsujimoto Gozoh, Ishihara Akihiko, Tsuda Kinsuke, Yasuda Koichiro. Sucrase-isomaltase gene expression is inhibited by mutant hepatocyte nuclear factor (HNF)-1alpha and mutant HNF-1beta in Caco-2 cells. J Nutrl Sci Vitaminol. 52(2), 105-112, Apr, 2006.

17) Gu Ning, Suzuki Naoko, Takeda Jun, Adachi Tetsuya, Tsujimoto Gozoh, Ishihara Akihiko,Tsuda Kinsuke, Yasuda Koichiro. Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase (SI) in Caco-2 cells. Biochem Biophys Res Commun. 325(1), 308-313, Oct, 2004.

18) Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Takeda Isao, Tsuda Kinsuke, Ishihara Akihiko. Characteristics of skeletal muscle in rats with diabetes, hypertension, obesity,and hyperlipidemia. J Atheroscler Thromb. 16(5), 576-585, Oct, 2009.

19) Nagatomo Fumiko, Gu Ning, Fujino Hidemi, Okiur Tomonori, Morimatsu Fumiki, Takeda Isao, Ishihara Akihiko. Effects of hyperbaric exposure with high oxygen concentration on reactive oxygen metabolites in type II collagen-induced arthritis rats. Free Radical Research (accepted Aug, 2009).

20) Matsunaga Tetsuro, Gu Ning, Yamazaki Hanae, Tsuda Mariko, Adachi Tetsuya, Yasuda ,Koichiro, Moritani, Toshio, Tsuda Kinsuke, Nonaka Masahiko, Nishiyama Tohru. Association of UCP2 and UCP3 polymorphisms with autonomic nervous system functionin young Japanese males. J Hypertens. 27(2), 305-313, 2009.

21) Okiura Tomonori, Nagatomo Fumiko, Gu Ning, Taguchi Yasuki, Morimatsu Fumiki and Ishihara Akihiko. Bone density of the femur and fFiber cross-sectional area and oxidative enzyme activity of the tibialis anterior muscle in type II collagen-induced arthritic mice. J Physiol Sci. 58(4), 221-227, 2008.

22) Koyanagi Midori, Nakabayashi Kazuhiko, Fujimoto Takahiro, Gu Ning, Baba Iwai, Sasazuki Takehiko and Shirasawa Senji. ZFAT expression in B and T lymphocytes andidentification of ZFAT-regulated genes. Genomics. 91(5), 451-457, 2008.

23) Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Matsumoto Akiko, Matsunaga Tetsuro, Tsujimoto Gozoh, Ishihara Akihiko. Effects of hyperbaric exposure with high oxygenconcentration on glucose and insulin levels and skeletal muscle fiber properties in diabetic Goto-Kakizaki rats. Muscle Nerve. 35(3), 337-343, 2007.

24) Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males. Am Heart J.154(4), 759-766, 2007.

25) Adachi Tetsuya, Kikuchi Naoko, Yasuda Koichiro, Anahara Reko, Gu Ning, Matsunaga Tetsuro, Yamamura Tsubasa, Tsujimoto Gozou, Tsuda Kinsuke, Ishihara Akihiko. Fiber type distribution, succinate dehydrogenese and peroxisome proliferator- activatedreceptor gamma coactivator- 1alpha gene expression level of fibers in the soleus muscle of Zucker diabetic fatty rats. Exp Physiol. 92(2), 449-455, 2007.

26) Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Tsuda Kinsuke, Kikuchi Naoko, Matsunaga Tetsuro, Ishihara Akihiko. Hyperbaric exposure with high oxygen concentration inhibits growth-associated increase in the glucose level of diabetic Goto-Kakizaki rats. Diabetes Obes Metab. 8(6), 714-715, 2006.

27) Matsunaga Tetsuro, Yasuda Koichiro, Adachi Tetsuya, Gu Ning, Yamamura Tsubasa, Moritani Toshio, Tsujimoto Gozoh, Tsuda Kinsuke. Alpha-adrenoceptor gene variants and autonomic nervous system function in a young healthy Japanese population. J Hum Genet. 52(1), 28-37, 2006.

28) Matsunaga Tetsuro, Nagasumi Kae, Gu Ning, Nishikino Mariko, Ueda Yukihiko, Moritani Toshio, Aoki Norihiko, Tsuda Kinsuke, Yasuda Koichiro. Association of C825T Polymorphism of G protein beta3 subunit with the autonomic nervous system in young healthy japanese individuals. Am J Hypertens. 18(4), 523-529, 2005.

29) Yasuda Koichiro, Matsunaga Tetsuro, Moritani Toshio, Nishikino Mariko, Gu Ning, Yoshinaga Mariko, Nagasumi Kae, Yamamura Tsubasa,, Tsuda Kinsuke. T393C polymorphism of GNAS1 associated with the autonomic nervous system in young, healthy Japanese subjects. Clin Exp Pharm Phys. 31(9), 597-601, 2004.